LIGANDROLE
LGD-4033 or commonly known as Ligandrol works by binding to androgen receptors but with rather high affinity and selectivity. Like testosterone, it also exhibits therapeutic benefits similar to testosterone, which includes significant effects in treating muscle wasting disease. However, it also contributes to anabolic activity in bone, being strongly selective for muscle and bone versus prostate and sebaceous glands. LGD-4033 is equivalent to a mixture of testosterone and Dianabol.
Clinical trial
Several experiments that have been conducted to study the effects of LGD-4033 have shown that it has almost similar effects to testosterone which includes an increase in lean body mass and a decrease in body fat. However, there are other effects as well, such as a substantial increase in strength and recoverability. Dosages for clinical trials reach up to 22mg/day.
Benefit
Like testosterone, the effects of LGD-4033 are not limited to just the fitness aspect as it also has many medical benefits. It has shown a strong ability in treating ailments related to muscle wasting, especially age-related problems. In terms of fitness, LGD-4033 can be used for bulking, recomp and cutting, but positively leans more towards bulking and recomp. Like dianabol, bulking using LGD-4033 will require a proper diet with a substantial increase in calorie intake. However, for rearranging and cutting, stacking Ligandrol with another SARM suitable for cutting, specifically Cardarine, S-4 or Ostarine will result in better lean gains and faster fat loss.
Side effects
Although there are no major side effects with the use of LGD-4033, it still shows signs of suppression that are more dose dependent. However, despite the suppression, the recovery is not far from the use of anabolic steroids. However, Ligandrol has a higher degree of suppression compared to all other SARMs. Thus, it is advisable to have an aromatase inhibitor with a full PCT cycle.
Dose
Bulking: 5-10mg/day (8 weeks)
Cutting: 3-5mg/day (8 weeks)
PCT
Week 9-10 Nolvadex (40 mg per day) and Clomid (50 mg per day)
Week 11-12 Nolvadex (20 mg per day) and Clomid (25 mg per day)
GHBEAST
MK-677 or commonly known as Nutrobal basically secretes growth hormone through oral ingestion. Once consumed, it chemically signals the pituitary gland to release growth hormone. Nutrobal is constantly being compared to the likes of GHRP-6. However, it has no side effects and does not require injection like GHRP-6. In essence, Growth Hormone pulse intensity can be increased through 4 possible mechanisms:
- Increases GHRH (growth hormone release).
- Amplifies GHRH signals in anterior pituitary gland somatotrophs.
- Reduces somatostatin release (somatostatin shuts down GH release).
- Inhibits somatostatin receptor signaling.
- Nutrobal has been found to be effective in all 4 of these mechanisms as on ingestion, Growth Hormone is significantly increased with steady doses starting at 5mg/day.
Clinical trial
Based on a preliminary clinical trial of a 25mg/day dose of Nutrobal, subjects after being administered the same number of doses for 7 days have shown a drastic increase in both IGF-1 and GH levels. Subjects also demonstrated reversal of nitrogen wastage, which in further development could be used as a potential treatment involving muscle wasting. An experiment was also conducted to examine the effect of Nutrobal on obesity, in which subjects gained considerable lean body mass due to the high calorie deposition directly into the muscles and inducing decreased appetite. Compared to commonly used methods to target fat storage directly which is excessive and harmful. Another experimental study was also conducted to study the effects of Nutrobal on osteoporosis, where it was found to increase bone density, thereby helping to heal bones. All of this research has also led to the discovery of Nutrobal's potential in improving a person's sleep, skin tone, energy levels, immunity levels, strength and overall well-being.
Benefit
In a broader perspective, based on the research conducted, there are 2 main results from Nutrobal to the human body which lies in the increase in GH and IGF-1 levels. Both of these areas are quite effective in providing benefits for fitness enthusiasts by increasing muscle mass. It does not provide the amount of intense GH levels that are present in a given HGH injection. Instead, it will significantly increase the level of naturally produced GH which is much safer and less painful. The focus is on IGF-1 levels, which have been seen to increase by up to 89% with Nutrobal consumption and benefit the body in these areas:
- Increased Fat Oxidation
- Increase Lean Muscle Gain
- Tighten sagging skin
- Heal the previous wound
- Healing Bones, Tendons and Ligaments
Side effects
The side effects of Nutrobal are usually caused by an increase in GH levels in the body which usually causes numbness of the hands, fatigue, and possibly an increase in appetite, all of which are not a cause for concern. However, users prone to prolactin should take precautions using HCG but no PCT is required.
Dose
12.5-25mg/day (10 weeks).
OSTARINE
MK-2866 or commonly known as Ostarine binds directly to muscle receptors causing muscle growth that is very similar to muscle growth based on steroids but without the accompanying side effects. In fact, the gains arising from the use of Ostarine are very much sustained after a cycle as long as the workouts are consistent. This is very different from steroid use which usually causes some gains to be lost post cycle. If there is a comparison, the closest anabolic steroid that matches Ostarine's properties is Anavar.
Clinical trial
Ostarine was first developed by Gtx whose function was originally directed to combat muscle wasting disease. However, in early trials, Ostarine was shown to be a more potent version of Anavar, where it showed a significant increase in muscle growth in all of its subjects. Continuous use of Ostarine also revealed that it resulted in a statistically significant increase in lean body mass and an increase in overall physical performance.
Benefit
Based on its clinical trials, the benefits of Ostarine are not limited to it as a treatment for muscle wasting disease. It has been shown to be more efficient at increasing lean muscle and reducing fat, where it greatly increases glucose and insulin levels in the user's system. Besides being more useful in terms of fitness, this increase in glucose and insulin will also help with all types of prediabetes.
Side effects
With the right dosage, there don't seem to be any side effects with Ostarine as it shows no signs of being suppressive. However, prolonged use or higher doses seem to make it a little depressing but not as serious as the side effects of steroid use. It is recommended to do a mini PCT after an Ostarine cycle.
Dose
Men: 12.5-25mg/day (8 weeks)
PCT
Week 9-10 Clomid (50 mg per day)
Week 11-12 Clomid (25 mg per day)
